Bioactivity of Combination Elephantopus scaber and Sauropus androgynus on the Level of B220 cells of Lymph Node in Pregnant Typhoid BALB/c Mice

Authors

  • Lulut Dwi Nurmamulyosari master of biology university of brawijaya
  • Muhammad Sasmito Djati dept. of biology university of brawijaya
  • Sri Widyarti dept. of biology university of brawijaya

DOI:

https://doi.org/10.21776/ub.jels.2015.005.02.03

Abstract

Elephantopus scaber and Sauropus androgynus are herbal remedies that contain flavonoids as immunomodulatory agents. This study was aimed to observe the changes in the relative number of B cells in lymph node tissue of pregnant typhoid mice. Mice were divided into seven groups K-, K+, E. scaber 200 mg.kg-1 BW,  E. scaber 150 mg.kg-1 BW + S. androgynus 37.5 mg.kg-1 BW,  E. scaber 100 mg.kg-1 BW + S. androgynus 75 mg.kg-1 BW,  E. scaber 50 mg.kg-1 BW + S. androgynus 112.5 mg.kg-1 BW, dan S. androgynus 150 mg.kg-1 BW. Mice were dissected on the 12th and 18th day after herbal treatment. Data was analyzed using one way ANOVA (p < 0.05) and Duncan. The result show that E. scaber combination of 200 mg.kg-1 BW and E. scaber 150 mg.kg-1 BW + S. androgynus 37.5 mg.kg-1 BW can increase the number of B220 cells (p < 0,05) on pregnant mice typoid model.

Keywords: B220, Elephantopus scaber, pregnant, Sauropus androgynus, typhoid fever

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Published

2015-11-04

Issue

Vol. 5 No. 2 (2015)

Section

Articles

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